On today's episode, we interview Dr. Jeffrey Flier, an esteemed endocrinologist and physician researcher who was Dean of the Faculty of Medicine at Harvard University for nine years (2007-2016). We talk about his career in academic medicine as well as the challenges of 2021.

Today we bring back popular guest Dr. David Russler-Germain, a Hematology/Oncology Fellow at the Washington University School of Medicine in St. Louis, to discuss his thoughts on PhD programs (in response to a listener question) as well as his take on Idecabtagene vicleucel for multiple myeloma.

Today we talk with Dr. Martin Kulldorff, a Professor of Medicine at Harvard Medical School and Brigham and Women's Hospital, about COVID-19 health policy and about disagreement.

Today we bring back popular guest Dr. Adam Cifu, a Professor of Medicine at the University of Chicago, to talk about the idea of banning books. the power of social media, and the current state of medical education.

Today we are joined by Samantha Godwin, a Resident Fellow for the Information Society Project at Yale Law School, to discuss COVID-19 health policy from a legal and philosophical perspective.

Today we talk again with Dr. David Russler-Germain, a Hematology/Oncology Fellow at the Washington University School of Medicine in St. Louis, this time on the Medical Scientist Training Program (MSTP).

Today we interview Dr. Tom Beer, the Deputy Director of the Oregon Health & Science University Knight Cancer Institute, about COVID-19 transmission, policy, and vaccines. We also talk about olaparib.

Today we are joined by guest Dr. Carl Hart, a behavioral neuroscientist and Professor of Psychology at Columbia University. We discuss his research, his philosophies, and his new book "Drug Use for Grown-Ups.”

Today we bring back popular guest Dr. Bernie Marini, a Clinical Pharmacist Specialist in Hematology at University of Michigan Medicine, to discuss treatment of Acute Lymphoblastic Leukemia (ALL).

Today we are joined by genomicist Dr. Nathan Pearson, founder of Root (rootdeep.com), to discuss which genetic alterations in the host predispose to SARS-CoV-2 acquisition and bad outcomes.

Today we bring back popular guest Jacob Hale Russell, an Associate Professor of Law at Rutgers Law School, for a discussion on expertise, disinformation, and intellectual disagreement.

On today's episode we talk with popular guest Dr. Chris Booth of Queen's University in Kingston, Ontario, Canada about mapping out a career path after medical school and about his new paper out now in JAMA Oncology titled "Evolution of the Randomized Clinical Trial in the Era of Precision Oncology".

Today we interview Dr. Ghulam Rehman Mohyuddin of Kansas University Medical Center on his new paper out now in The Lancet Haematology titled "Quality of control groups in randomised trials of multiple myeloma enrolling in the USA: a systematic review".

Today we sit down with Dr. Matthew Smith, an associate professor in the Northeastern University Department of Philosophy and Religion, to discuss the morality and philosophical backbone behind COVID-19 vaccine distribution and how we should define equity; cancel culture and its historical longevity; and the impossibility (at least in the USA) of Zero COVID-19.

For today's episode we have a short monologue in remembrance of famed cancer researcher Dr. José Baselga.

Today we interview Dr. Bob Wachter, the Chair of the Department of Medicine at University of California San Francisco. We talk about a wide range of topics including medicine, leadership, SARS-CoV-2, and social media.

On today's episode we interview Youyang Gu, an independent data scientist who created some of the most models of the COVID-19 pandemic. He talks us through how he made the projections. His work is available on his website: https://covid19-projections.com/

On today's SHORT episode, we talk about censorship, Facebook, Twitter, and the "evildoer" Dr. Marty Makary.

Today we interview Dr. Robert Freudenthal, a psychiatrist in training at Barnet Enfield and Haringey Mental Health Trust in London, UK. We talk abut the power of the state and its role in public health policy. We focus specifically on how governments worldwide have responded to the COVID-19 pandemic, from extreme lockdowns to harm reduction advisories. We discuss how policy can be medical overreach as well as how it interplays with the criminal justice system and racial and class inequities. Finally, we discuss censorship and the need for trust and honesty in messaging.

Today we interview Dr. Luc Morris of Memorial Sloan Kettering Cancer Center on his new paper out now in JAMA Oncology titled "Response Rates to Anti-PD-1 Immunotherapy in Microsatellite-Stable Solid Tumors With 10 or More Mutations per Megabase".